High-fidelity DNA replication is critical for the faithful transmission of genetic information to
daughter cells. Following genotoxic stress, specialized DNA damage tolerance pathways …

The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …

Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key
genetic step that complements activation of KRAS in promoting the development and …

Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy
for treating various diseases, especially cancer. Over almost three decades, although great …

Simple Summary Osimertinib, a third-generation epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor, is currently indicated as first-line therapy in patients with non-small …

Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been
approved or have undergone clinical trials and their therapeutic application in multiple …

Alzheimer's disease (AD) is a serious neurodegenerative disease characterized by memory
impairment, mental retardation, impaired motor balance, loss of self-care and even death …

CDK9 plays a vital role in regulating RNA transcription and significantly impacts the
expression of short-lived proteins such as Mcl-1 and c-Myc. Thus, targeting CDK9 holds …

Meriolin derivatives represent a new class of kinase inhibitors with a pronounced cytotoxic
potential. Here, we investigated a newly synthesized meriolin derivative (termed meriolin 16) …

Simple Summary Nowadays, the upfront treatment for patients facing a diagnosis of
advanced luminal breast cancer (BC) is a combination of endocrine therapy (ET) with an …