Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Almost all of the 200 or so approved biopharmaceuticals have been produced in one of
three host systems: the bacterium Escherichia coli, yeasts (Saccharomyces cerevisiae …

Motivation Protein solubility plays a vital role in pharmaceutical research and production
yield. For a given protein, the extent of its solubility can represent the quality of its function …

Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …

Microalgae are potential feedstocks for the commercial production of carotenoids, however,
the metabolic pathways for carotenoid biosynthesis across algal lineage are largely …

A common limitation of recombinant protein production in bacteria is the formation of
insoluble protein aggregates known as inclusion bodies. The propensity of a given protein to …

Poor protein solubility is a common problem in high-resolution structural studies, formulation
of protein pharmaceuticals, and biochemical characterization of proteins. One popular …

Protein solubility is an important thermodynamic parameter that is critical for the
characterization of a protein's function, and a key determinant for the production yield of a …

Background The expression of heterologous proteins in Escherichia coli is strongly affected
by codon bias. This phenomenon occurs when the codon usage of the mRNA coding for the …

High concentration protein delivery is difficult to achieve for several protein pharmaceuticals
due to low solubility. In this review, we discuss different types of low protein solubility …