The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Laminopathies, caused by mutations in the LMNA gene encoding the nuclear envelope
proteins lamins A and C, represent a diverse group of diseases that include Emery–Dreifuss …

The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …

Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including
dystrophies of the skeletal muscle and fat, dilated cardiomyopathy, and progeria-like …

Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of
disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide …

Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

Lamins, the major components of the nuclear lamina, have gained rapidly increasing
interest over the past decade as lamin mutations were found to cause numerous devastating …

The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …