Mechanisms of Antibiotic Resistance in Burkholderia Pseudomallei: Implications for Treatment of Melioidosis

HP Schweizer - Future microbiology, 2012 - Taylor & Francis
Burkholderia pseudomallei is the etiologic agent of melioidosis. This multifaceted disease is
difficult to treat, resulting in high morbidity and mortality. Treatment of B. pseudomallei …

Melioidosis: clinical impact and public health threat in the tropics

R Perumal Samy, BG Stiles, G Sethi… - PLoS neglected tropical …, 2017 - journals.plos.org
This review briefly summarizes the geographical distribution and clinical impact of
melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative …

Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis

R Pankla, S Buddhisa, M Berry, DM Blankenship… - Genome biology, 2009 - Springer
Background Melioidosis is a severe infectious disease caused by Burkholderia
pseudomallei, a Gram-negative bacillus classified by the National Institute of Allergy and …

[PDF][PDF] Melioidosis in the Americas

TJJ Inglis, DB Rolim, ADQ Sousa - The American journal of tropical …, 2006 - Citeseer
Melioidosis is a potentially severe bacterial infection caused by Burkholderia pseudomallei.
There has been growing awareness of the disease in the Americas, particularly since the …

[HTML][HTML] The treatment of melioidosis

TJJ Inglis - Pharmaceuticals, 2010 - mdpi.com
Melioidosis is a complex bacterial infection, treatment of which combines the urgency of
treating rapidly fatal Gram negative septicaemia with the need for eradication of long-term …

Highly sensitive direct detection and quantification of Burkholderia pseudomallei bacteria in environmental soil samples by using real-time PCR

TT Trung, A Hetzer, A Göhler, E Topfstedt… - Applied and …, 2011 - Am Soc Microbiol
The soil bacterium and potential biothreat agent Burkholderia pseudomallei causes the
infectious disease melioidosis, which is naturally acquired through environmental contact …

Contact investigation of melioidosis cases reveals regional endemicity in Puerto Rico

TJ Doker, TM Sharp, B Rivera-Garcia… - Clinical Infectious …, 2015 - academic.oup.com
Investigation of melioidosis cases in eastern Puerto Rico revealed high rates of Burkholderia
pseudomallei seropositivity, and the bacterium was isolated from soil, suggesting regional …

Burkholderia Pseudomallei Causing Bone and Joint Infections: A Clinical Update

NS Raja, C Scarsbrook - Infectious Diseases and Therapy, 2016 - Springer
Abstract Burkholderia pseudomallei (B. pseudomallei), a causative agent of an emerging
infectious disease melioidosis, is endemic in the tropical regions of the world. Due to …

Epetraborole, a leucyl-tRNA synthetase inhibitor, demonstrates murine efficacy, enhancing the in vivo activity of ceftazidime against Burkholderia pseudomallei, the …

JE Cummings, CS Lunde, MRK Alley… - PLOS Neglected …, 2023 - journals.plos.org
Burkholderia pseudomallei is the causative agent of melioidosis, which is increasingly being
reported worldwide. Mortality rates as high as 40% have been reported based on clinical …

Exploitation of the bilosome platform technology to formulate antibiotics and enhance efficacy of melioidosis treatments

RV D'Elia, S Woods, W Butcher, J McGahon… - Journal of controlled …, 2019 - Elsevier
Burkholderia pseudomallei is a Gram-negative intracellular bacterium which is recalcitrant to
antibiotic therapy. There also is currently no licensed vaccine for this potentially fatal …