Evolution of glutamatergic signaling and synapses

LL Moroz, MA Nikitin, PG Poličar, AB Kohn… - …, 2021 - Elsevier
Glutamate (Glu) is the primary excitatory transmitter in the mammalian brain. But, we know
little about the evolutionary history of this adaptation, including the selection of l-glutamate …

Targeting calcium homeostasis and impaired inter-organelle crosstalk as a potential therapeutic approach in Parkinson's disease

S Kaur, A Sehrawat, SS Mastana, R Kandimalla… - Life Sciences, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra pars compacta, leading to motor …

Syncytial nerve net in a ctenophore adds insights on the evolution of nervous systems

P Burkhardt, J Colgren, A Medhus, L Digel, B Naumann… - Science, 2023 - science.org
A fundamental breakthrough in neurobiology has been the formulation of the neuron
doctrine by Santiago Ramón y Cajal, which stated that the nervous system is composed of …

Neuron–glia interaction in the Drosophila nervous system

J Bittern, N Pogodalla, H Ohm, L Brüser… - Developmental …, 2021 - Wiley Online Library
Animals are able to move and react in manifold ways to external stimuli. Thus,
environmental stimuli need to be detected, information must be processed, and, finally, an …

Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses

A Senatore, TS Reese… - Journal of Experimental …, 2017 - journals.biologists.com
Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and
grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the …

In vivo neuromodulation of animal behavior with organic semiconducting oligomers

G Tommasini, M De Simone, S Santillo, G Dufil… - Science …, 2023 - science.org
Modulating neural activity with electrical or chemical stimulus can be used for fundamental
and applied research. Typically, neuronal stimulation is performed with intracellular and …

Sensing the world and its dangers: an evolutionary perspective in neuroimmunology

A Kraus, KM Buckley, I Salinas - Elife, 2021 - elifesciences.org
Detecting danger is key to the survival and success of all species. Animal nervous and
immune systems cooperate to optimize danger detection. Preceding studies have …

Coherent directed movement toward food modeled in Trichoplax, a ciliated animal lacking a nervous system

CL Smith, TS Reese, T Govezensky… - Proceedings of the …, 2019 - National Acad Sciences
Trichoplax adhaerens is a small, ciliated marine animal that glides on surfaces grazing upon
algae, which it digests externally. It has no muscles or nervous system and only six cell …

Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals

DY Romanova, IV Smirnov, MA Nikitin, AB Kohn… - Biochemical and …, 2020 - Elsevier
Placozoa are small disc-shaped animals, representing the simplest known, possibly
ancestral, organization of free-living animals. With only six morphological distinct cell types …

Evolutionary Analysis of Cnidaria Small Cysteine-Rich Proteins (SCRiPs), an Enigmatic Neurotoxin Family from Stony Corals and Sea Anemones (Anthozoa …

RA Barroso, L Ramos, H Moreno, A Antunes - Toxins, 2024 - mdpi.com
Cnidarians (corals, sea anemones, and jellyfish) produce toxins that play central roles in key
ecological processes, including predation, defense, and competition, being the oldest extant …