In development, morphogenetic processes are strictly coordinated in time. Cells in a
developing tissue would need mechanisms for time‐keeping. One such time‐keeping …

Fractional killing illustrates the cell propensity to display a heterogeneous fate response
over a wide range of stimuli. The interplay between the nonlinear and stochastic dynamics of …

Proper tissue development requires that stem/progenitor cells precisely coordinate cell
division and differentiation in space and time. Notch-Hes1 intercellular signaling, which …

Abstract The Delta-Notch-Hes signaling pathway is involved in various developmental
processes ranging from the formation of somites to the dynamic fine-grained patterns of cell …

The proper functioning of multicellular organisms requires the robust establishment of
precise proportions between distinct cell types. This developmental differentiation process …

From population collapses to cell-fate decision, critical phenomena are abundant in complex
real-world systems. Among modelling theories to address them, the critical transitions …

The motivation of this volume stems from our experience on plant development using bottom-
up system biology approaches, as well as our investigations in several human health …

MAPK and PI3K− Akt− mTOR signaling cascades regulate important cellular processes.
There was developed the mathematical model that was used for the analysis of the …

Starting from pluripotent stem cells that virtually proliferate indefinitely, the orderly
emergence during organogenesis of lineage-restricted cell types exhibiting a decreased …

The segmentation of the anteroposterior axis in somites is a major feature of Vertebrates.
This process relies on an oscillator, the “segmentation clock”. The present thesis addresses …