The synthetic antithrombin-binding heparin pentasaccharide and a full-length heparin of
approximately 26 saccharides containing this specific sequence have been compared with …

Despite many studies on the pathophysiology of antiphospholipid antibodies (aPL), the
mechanism by which aPL causes thrombosis has not been established. We have tried to …

Activation of human platelets considerably enhanced their ability to accelerate factor Va
inactivation by activated protein C (APC). The anticoagulant activity of platelet suspensions …

Factor V was purified from the plasma of an activated protein C (APC)-resistant patient who
is homozygous for the mutation Arg 506→ Gln (factor V R506Q). Factor V R506Q was …

Inactivation of membrane-bound factor Va by activated protein C (APC) proceeds via a
biphasic reaction that consists of a rapid and a slow phase, which are associated with …

We describe a novel phage display system that affords the surface expression and hence
affinity selection of cDNAs. The strategy is based on a new approach to functionally display …

To determine the role of individual saccharide residues of a specific heparin
pentasaccharide, denoted DEFGH, in the allosteric activation of the serpin, antithrombin, we …

Human hookworm infection is a major cause of gastrointestinal blood loss and iron
deficiency anemia, affecting up to one billion people in the developing world. These soil …

Heparin activates the primary serpin inhibitor of blood clotting proteinases, antithrombin,
both by an allosteric conformational change mechanism that specifically enhances factor Xa …

β 2-glycoprotein I (β 2 GPI) is a plasma glycoprotein with unknown physiological function (s).
In in vitro experiments it has been demonstrated that β 2 GPI has both anticoagulant …