[HTML][HTML] Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds

A Pfalzgraff, K Brandenburg, G Weindl - Frontiers in pharmacology, 2018 - frontiersin.org
Alarming data about increasing resistance to conventional antibiotics are reported, while at
the same time the development of new antibiotics is stagnating. Skin and soft tissue …

[HTML][HTML] Chemical modifications to increase the therapeutic potential of antimicrobial peptides

Y Han, M Zhang, R Lai, Z Zhang - Peptides, 2021 - Elsevier
The continued use of antibiotics has been accompanied by the rapid emergence and spread
of antibiotic-resistant strains of bacteria. Antimicrobial peptides (AMPs), also known as host …

[HTML][HTML] Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

COVID‐19: Proposing a Ketone‐Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm

PC Bradshaw, WA Seeds, AC Miller… - Oxidative Medicine …, 2020 - Wiley Online Library
Human SARS‐CoV‐2 infection is characterized by a high mortality rate due to some patients
developing a large innate immune response associated with a cytokine storm and acute …

Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF

CJ Slavetinsky, JN Hauser, C Gekeler, J Slavetinsky… - Elife, 2022 - elifesciences.org
The pandemic of antibiotic resistance represents a major human health threat demanding
new antimicrobial strategies. Multiple peptide resistance factor (MprF) is the synthase and …

Advanced role of neutrophils in common respiratory diseases

J Liu, Z Pang, G Wang, X Guan, K Fang… - Journal of …, 2017 - Wiley Online Library
Respiratory diseases, always being a threat towards the health of people all over the world,
are most tightly associated with immune system. Neutrophils serve as an important …

The LL-37 domain: A clue to cathelicidin immunomodulatory response?

ML Leite, HM Duque, GR Rodrigues, NB da Cunha… - Peptides, 2023 - Elsevier
Host defense peptides (HDPs) are naturally occurring polypeptide sequences that, in
addition to being active against bacteria, fungi, viruses, and other parasites, may stimulate …

Cathelicidin‐related antimicrobial peptide promotes neuroinflammation through astrocyte–microglia communication in experimental autoimmune encephalomyelitis

A Bhusal, Y Nam, D Seo, MH Rahman, EM Hwang… - Glia, 2022 - Wiley Online Library
Cathelicidin‐related antimicrobial peptide (CRAMP) is an effector molecule of the innate
immune system with direct antimicrobial and immunomodulatory activities; however, its role …

Extending the vitamin D pathway to vitamin D3 and CYP27A1 in periodontal ligament cells

C Zhang, K Liu, J Hou - Journal of Periodontology, 2021 - Wiley Online Library
Background In periodontal connective tissue cells, the vitamin D pathway has been
elucidated, and vitamin D3 in the main storage form, 25‐hydroxy vitamin D3 (25 [OH] D3) …

[HTML][HTML] Native pig neutrophil products: insights into their antimicrobial activity

E Fernández-De La Cruz, J Wessely-Szponder… - Microorganisms, 2023 - mdpi.com
Cationic antimicrobial peptides are molecules with potential applications for treating
infections due to their antimicrobial and immunomodulatory properties. The aim of this work …