Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

Mitochondria tailor their morphology to execute their specialized functions in different cell
types and/or different environments. During spermatogenesis, mitochondria undergo …

The mechanisms regulating meiotic initiation in mammals are enigmatic. It is known that
retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is …

In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate
to eventually become spermatozoa. This delicate balance must be maintained, as defects …

Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial
differentiation and meiotic differentiation that are both essential for the generation of …

Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia
responsible for ongoing spermatogenesis in mammalian testes. Spermatogonial stem cells …

Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-
amplifying progenitors that differentiate in response to retinoic acid (RA) before entering …

Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm
production depends on the exact regulation of the microenvironment in the testes. Many …

Prospermatogonia transition into type A spermatogonia, which provide the source for the
spermatogonial stem cell (SSC) pool. A percentage of these type A spermatogonia then …

We hypothesised that antenatal exposure to ubiquitous phthalates may lead to an earlier
menarche and a lower prevalence of polycystic ovarian syndrome (PCOS) and polycystic …