Neurodegenerative diseases are debilitating disorders that feature progressive and
selective loss of function or structure of anatomically or physiologically associated neuronal …

Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …

Electromagnetic fields (EMFs) originating both from both natural and manmade sources
permeate our environment. As people are continuously exposed to EMFs in everyday life, it …

The choroid plexus (CP) of the blood–CSF barrier (BCSFB) displays fundamentally different
properties than blood-brain barrier (BBB). With brisk blood flow (10× brain) and highly …

Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …

Background Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied
during the 'preclinical'stage (pathology present with cognition intact) before severe neuronal …

Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR)
ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR–β-amyloid (Aβ) …

Liraglutide is a GLP-1 analog (glucagon like peptide-1) used primarily in the treatment of
diabetes mellitus type 2 (DM2) and obesity. The literature starts to suggest that liraglutide …

The protein homeostasis (proteostasis) system encompasses the cellular processes that
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …

Alzheimer's disease (AD) is the most common form of dementia worldwide, being
characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the …