Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during
which the maternal environment is converted to an environment of embryonic-driven …

In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which consists
of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …

Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …

Histone post-translational modifications are key gene expression regulators, but their rapid
dynamics during development remain difficult to capture. We applied a Fab-based live …

Background Eukaryotic genomes are partitioned into euchromatic and heterochromatic
domains to regulate gene expression and other fundamental cellular processes. However …

Recent advances in single-cell sequencing technologies have enabled simultaneous
measurement of multiple cellular modalities, but the combined detection of histone post …

Background Early embryonic developmental programs are guided by the coordinated
interplay between maternally inherited and zygotically manufactured RNAs and proteins …

Background The regulation of messenger RNA (mRNA) stability has a profound impact on
gene expression dynamics during embryogenesis. For example, in animals, maternally …