Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell
apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

Although it is known that mTOR complex 2 (mTORC2) functions upstream of Akt, the role of
this protein kinase complex in cancer is not well understood. Through an integrated analysis …

cFLIP (cellular FLICE-like inhibitory protein) is structurally related to caspase-8 but lacks
proteolytic activity due to multiple amino acid substitutions of catalytically important residues …

The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the
detailed mechanism is unclear. In this study, we investigated the interactive effects of p53 …

Ovarian cancer (OVCA) is the most lethal gynecological cancer, due predominantly to late
presentation, high recurrence rate and common chemoresistance development. The …

Abnormal epigenetic regulation is identified to correlate with cancer progression and
renders tumor refractory and resistant to reactive oxygen species (ROS)‐based anti‐tumor …