Neuroprosthetics: from sensorimotor to cognitive disorders

A Gupta, N Vardalakis, FB Wagner - Communications biology, 2023 - nature.com
Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …

The benefits and mechanisms of exercise training for Parkinson's disease

YS Feng, SD Yang, ZX Tan, MM Wang, Y Xing, F Dong… - Life sciences, 2020 - Elsevier
Parkinson's disease (PD) is a significantly progressive neurodegenerative disease
characterised by both motor and nonmotor disorders. The main pathological characteristics …

Motor learning deficits in Parkinson's disease (PD) and their effect on training response in gait and balance: a narrative review

M Olson, TE Lockhart, A Lieberman - Frontiers in neurology, 2019 - frontiersin.org
Parkinson's disease (PD) is a neurological disorder traditionally associated with
degeneration of the dopaminergic neurons within the substantia nigra, which results in …

Neural substrates of the drift-diffusion model in brain disorders

A Gupta, R Bansal, H Alashwal, AS Kacar… - Frontiers in …, 2022 - frontiersin.org
Many studies on the drift-diffusion model (DDM) explain decision-making based on a unified
analysis of both accuracy and response times. This review provides an in-depth account of …

A single bout of aerobic exercise improves motor skill consolidation in Parkinson's disease

S Steib, P Wanner, W Adler, J Winkler… - Frontiers in aging …, 2018 - frontiersin.org
Background: Motor learning is impaired in Parkinson's disease (PD), with patients
demonstrating deficits in skill acquisition (online learning) and consolidation (offline …

Akinetic rigid symptoms are associated with decline in a cortical motor network in Parkinson's disease

SJ Kann, C Chang, P Manza, HC Leung - NPJ Parkinson's disease, 2020 - nature.com
The akinetic/rigid (AR) motor subtype of Parkinson's Disease is associated with increased
rates of motor and cognitive decline. Cross-sectional studies examining the neural …

Neural correlates of dual-task walking in people with central neurological disorders: A systematic review

H Kim, S Fraser - Journal of Neurology, 2022 - Springer
Background People with central neurological disorders experience difficulties with dual-task
walking due to disease-related impairments. The objective of this review was to provide a …

Cognitive parameters can predict change of walking performance in advanced Parkinson's disease–Chances and limits of early rehabilitation

J Geritz, J Welzel, C Hansen, C Maetzler… - Frontiers in aging …, 2022 - frontiersin.org
Introduction Links between cognition and walking performance in patients with Parkinson's
disease (PD), which both decline with disease progression, are well known. There is lack of …

Disentangling Bradykinesia and Rigidity in Parkinson Disease: Evidence from Short‐and Long‐Term Subthalamic Nucleus Deep Brain Stimulation

A Zampogna, A Suppa, F Bove, F Cavallieri… - Annals of …, 2024 - Wiley Online Library
Objective Bradykinesia and rigidity are considered closely related motor signs in Parkinson
disease (PD), but recent neurophysiological findings suggest distinct pathophysiological …

NOX2-derived hydrogen peroxide impedes the AMPK/Akt-mTOR signaling pathway contributing to cell death in neuronal cells

R Zhang, C Liu, L Yang, T Ji, N Zhang, X Dong… - Cellular signalling, 2022 - Elsevier
Oxidative stress is closely related to the pathogenesis of Parkinson's disease (PD), a typical
neurodegenerative disease. NADPH oxidase 2 (NOX2) is involved in hydrogen peroxide (H …