Transposable elements shape the evolution of mammalian development

AD Senft, TS Macfarlan - Nature Reviews Genetics, 2021 - nature.com
Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Viruses defined by the position of the virosphere within the replicator space

EV Koonin, VV Dolja, M Krupovic… - … and Molecular Biology …, 2021 - Am Soc Microbiol
Originally, viruses were defined as miniscule infectious agents that passed through filters
that retain even the smallest cells. Subsequently, viruses were considered obligate …

[HTML][HTML] Transposable elements

A Hayward, C Gilbert - Current Biology, 2022 - cell.com
Transposable elements are known by many names, including 'transposons','interspersed
repeats','selfish genetic elements','jumping genes', and 'parasitic DNA', but here we will refer …

Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling

DM Hermann, L Peruzzotti-Jametti, B Giebel… - Brain, 2024 - academic.oup.com
Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles
that convey complex signals between cells. EVs of different cellular sources are capable of …

A functional dissection of the mRNA and locally synthesized protein population in neuronal dendrites and axons

JD Perez, CM Fusco, EM Schuman - Annual Review of Genetics, 2021 - annualreviews.org
Neurons are characterized by a complex morphology that enables the generation of
subcellular compartments with unique biochemical and biophysical properties, such as …

The molecular memory code and synaptic plasticity: A synthesis

SJ Gershman - Biosystems, 2023 - Elsevier
The most widely accepted view of memory in the brain holds that synapses are the storage
sites of memory, and that memories are formed through associative modification of …

[HTML][HTML] Co-opting bacterial viruses for DNA exchange: structure and regulation of gene transfer agents

EJ Banks, TBK Le - Current Opinion in Microbiology, 2024 - Elsevier
Horizontal gene transfer occurs via a range of mechanisms, including transformation,
conjugation and bacteriophage transduction. Gene transfer agents (GTAs) are an …

Molecular physiology of Arc/Arg3. 1: The oligomeric state hypothesis of synaptic plasticity

MS Eriksen, CR Bramham - Acta Physiologica, 2022 - Wiley Online Library
The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …

Retrotransposons as drivers of mammalian brain evolution

R Ferrari, N Grandi, E Tramontano, G Dieci - Life, 2021 - mdpi.com
Retrotransposons, a large and diverse class of transposable elements that are still active in
humans, represent a remarkable force of genomic innovation underlying mammalian …

Phosphatidylinositol-3-phosphate mediates Arc capsid secretion through the multivesicular body pathway

K Mehta, H Yentsch, J Lee, Y Yook, KY Lee… - Proceedings of the …, 2024 - pnas.org
Activity-regulated cytoskeleton-associated protein (Arc/Arg3. 1) is an immediate early gene
that plays a vital role in learning and memory. Arc protein has structural and functional …