Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders
ES Lawrence, W Gu, RJ Bohlender… - Science …, 2024 - science.org
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …
nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated …
Hypoxia Inducible Factor pathway proteins in high-altitude mammals
FS Lee - Trends in biochemical sciences, 2024 - cell.com
Humans and other mammals inhabit hypoxic high-altitude locales. In many of these species,
genes under positive selection include ones in the Hypoxia Inducible Factor (HIF) pathway …
genes under positive selection include ones in the Hypoxia Inducible Factor (HIF) pathway …
Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success
S Ye, J Sun, SR Craig, A Di Rienzo, D Witonsky… - Proceedings of the …, 2024 - pnas.org
We chose the “natural laboratory” provided by high-altitude native ethnic Tibetan women
who had completed childbearing to examine the hypothesis that multiple oxygen delivery …
who had completed childbearing to examine the hypothesis that multiple oxygen delivery …
[HTML][HTML] Influence of Hypoxia on the Airway Epithelium
K Procházková, J Uhlík - Physiological Research, 2024 - pmc.ncbi.nlm.nih.gov
The necessity of oxygen for metabolic processes means that hypoxia can lead to serious cell
and tissue damage. On the other hand, in some situations, hypoxia occurs under …
and tissue damage. On the other hand, in some situations, hypoxia occurs under …
Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes
C Arenillas, J Ruiz-Cantador, L Celada, B Calsina… - bioRxiv, 2024 - biorxiv.org
EPAS1HIF2a is the primary gene implicated in systemic hypoxia adaptation. Conversely,
aberrantly activated EPAS1HIF2a acts as a tumor driver against which anti-tumor …
aberrantly activated EPAS1HIF2a acts as a tumor driver against which anti-tumor …