Biosynthesis of the bacterial antibiotic 3, 7-dihydroxytropolone through enzymatic salvaging of catabolic shunt products
L Höing, ST Sowa, M Toplak, JK Reinhardt… - Chemical …, 2024 - pubs.rsc.org
The non-benzenoid aromatic tropone ring is a structural motif of numerous microbial and
plant natural products with potent bioactivities. In bacteria, tropone biosynthesis involves …
plant natural products with potent bioactivities. In bacteria, tropone biosynthesis involves …
Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini
BC Richardson, ZR Turlington… - Biochemistry, 2024 - ACS Publications
A gene cluster responsible for the degradation of nicotinic acid (NA) in Bacillus niacini has
recently been identified, and the structures and functions of the resulting enzymes are …
recently been identified, and the structures and functions of the resulting enzymes are …
Ligand bound structure of a 6‐hydroxynicotinic acid 3‐monooxygenase provides mechanistic insights
ZR Turlington, SVF de Macedo, K Perry… - Archives of Biochemistry …, 2024 - Elsevier
Hydroxynicotinic acid 3-monooxygenase (NicC) is a bacterial enzyme involved in the
degradation of nicotinic acid. This enzyme is a Class A flavin-dependent monooxygenase …
degradation of nicotinic acid. This enzyme is a Class A flavin-dependent monooxygenase …