Epigenetic modifications are involved in global reprogramming of the cell transcriptome.
Therefore, synchronized major shifts in the expression of many genes could be achieved …

X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis,
promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is …

External constraints, such as development, disease, and environment, can induce changes
in epigenomic patterns that may profoundly impact the health trajectory of fetuses and …

Reactivation of the inactive X chromosome is a hallmark epigenetic event during
reprogramming of mouse female somatic cells to induced pluripotent stem cells (iPSCs) …

Induction and reversal of chromatin silencing is critical for successful development, tissue
homeostasis, and the derivation of induced pluripotent stem cells (iPSCs). X-Chromosome …

X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as
pluripotent cells differentiate. Once established, XCI is stably propagated, but can be …

Highlights•Cell–cell fusion is a tractable system for studying the earliest events in lineage
reprogramming.•There is untapped potential to combine cell–cell fusion and single cell …

Dosage compensation between XX female and XY male cells is achieved by a process
known as X chromosome inactivation (XCI) in mammals. XCI is initiated early during …

During cell fate transitions, cells remodel their transcriptome, chromatin, and epigenome;
however, it has been difficult to determine the temporal dynamics and cause-effect …

Mammalian females (XX) silence transcription on one of the two X chromosomes to
compensate the expression dosage with males (XY). This process—named X-chromosome …