The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

The brain's extracellular matrix (ECM) is a macromolecular network composed of
glycosaminoglycans, proteoglycans, glycoproteins, and fibrous proteins. In vitro studies …

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Silk refers to a family of natural fibers spun by several species of invertebrates such as
spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has …

The perineuronal net (PNN) represents a lattice‐like structure that is prominently expressed
along the soma and proximal dendrites of parvalbumin‐(PV‐) positive interneurons in varied …

Background Quantification of synapses and their morphological analysis are extensively
used in network development and connectivity studies, drug screening and other areas of …

The brain's extracellular matrix (ECM), a 3‐dimensional macromolecular network that
supports cell growth and viability, has crucial roles in homeostasis and disease. Accurate …