TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
Background Myeloid cells comprise up to 50% of the total tumor mass in glioblastoma (GBM)
and have been implicated in promoting tumor progression and immunosuppression …
and have been implicated in promoting tumor progression and immunosuppression …
Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression
ZP Tritz, K Ayasoufi, DM Wolf, CA Owens… - Cancer immunology …, 2023 - AACR
Glioblastoma (GBM) is the most common malignant brain tumor in adults, responsible for
approximately 225,000 deaths per year. Despite preclinical successes, most interventions …
approximately 225,000 deaths per year. Despite preclinical successes, most interventions …
MHC Class I Dependent and Independent T Cell Responses to Central Nervous System Insults: Studies in an Experimental Glioma and Theiler's Virus Systems
ZP Tritz - 2023 - search.proquest.com
MHC Class I molecules are classic drivers of CD8 T cell responses, with the strength and
affinity of peptide-loaded MHC molecules (pMHC) for particular T cell receptors (TCRs) …
affinity of peptide-loaded MHC molecules (pMHC) for particular T cell receptors (TCRs) …