An emerging role for sigma-1 receptors in the treatment of developmental and epileptic encephalopathies
P Martin, T Reeder, J Sourbron, PAM de Witte… - International journal of …, 2021 - mdpi.com
Developmental and epileptic encephalopathies (DEEs) are complex conditions
characterized primarily by seizures associated with neurodevelopmental and motor deficits …
characterized primarily by seizures associated with neurodevelopmental and motor deficits …
[PDF][PDF] Alzheimer's disease–Where do we go from here?
I Bezprozvanny - Biochemical and Biophysical Research …, 2022 - Elsevier
This is a very confusing and challenging time in Alzheimer's disease (AD) research. After life
expectancy was extended in industrial societies due to introduction of statins and reduced …
expectancy was extended in industrial societies due to introduction of statins and reduced …
Sigma-1 receptor (S1R) interaction with cholesterol: mechanisms of S1R activation and its role in neurodegenerative diseases
The sigma-1 receptor (S1R) is a 223 amino acid-long transmembrane endoplasmic
reticulum (ER) protein. The S1R modulates the activity of multiple effector proteins, but its …
reticulum (ER) protein. The S1R modulates the activity of multiple effector proteins, but its …
[HTML][HTML] Sigma-1 receptor activation induces autophagy and increases proteostasis capacity in vitro and in vivo
MG Christ, H Huesmann, H Nagel, A Kern, C Behl - Cells, 2019 - mdpi.com
Cells | Free Full-Text | Sigma-1 Receptor Activation Induces Autophagy and Increases
Proteostasis Capacity In Vitro and In Vivo Next Article in Journal Mycoplasma genitalium …
Proteostasis Capacity In Vitro and In Vivo Next Article in Journal Mycoplasma genitalium …
PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation
ZY Motawe, SS Abdelmaboud, J Cuevas… - The international journal …, 2020 - Elsevier
The discovery of a highly selective putative sigma-1 (σ1) receptor agonist, PRE-084, has
revealed the numerous potential uses of this receptor subtype as a therapeutic target. While …
revealed the numerous potential uses of this receptor subtype as a therapeutic target. While …
ANAVEX® 2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome
WE Kaufmann, J Sprouse, N Rebowe… - Pharmacology …, 2019 - Elsevier
Rett syndrome (RTT) is a severe neurodevelopmental disorder that is associated in most
cases with mutations in the transcriptional regulator MECP2. At present, there are no …
cases with mutations in the transcriptional regulator MECP2. At present, there are no …
Sigma-1 receptor agonists as potential protective therapies in multiple sclerosis
RP Lisak, L Nedelkoska, JA Benjamins - Journal of Neuroimmunology, 2020 - Elsevier
Abstract The sigma-1 receptor (σ-1R) is an endoplasmic reticulum (ER) chaperone
upregulated during ER stress, and regulates calcium homeostasis. Agonists of σ-1R are …
upregulated during ER stress, and regulates calcium homeostasis. Agonists of σ-1R are …
Advancing Alzheimer's disease treatment: Lessons from CTAD 2018
B Vellas, LJ Bain, J Touchon, PS Aisen - The Journal of Prevention of …, 2019 - Springer
Abstract The 2018 Clinical Trials on Alzheimer's Disease (CTAD) conference showcased
recent successes and failures in trials of Alzheimer's disease treatments. More importantly …
recent successes and failures in trials of Alzheimer's disease treatments. More importantly …