Efficient Preparation of the Key Intermediate in Corey's Tamiflu Synthesis

A novel and high-yielding asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from (−)-shikimic acid

LD Nie, W Ding, XX Shi, N Quan, X Lu - Tetrahedron: Asymmetry, 2012 - Elsevier
A novel and high-yielding asymmetric synthesis of oseltamivir phosphate 1 (Tamiflu®) is
described. The target compound 1 was obtained in 55% overall yield via an 11-step …
被引用次数：36 相关文章 所有 2 个版本

Novel asymmetric synthesis of oseltamivir phosphate (Tamiflu) from (−)-shikimic acid via cyclic sulfite intermediates

LD Nie, XX Shi, N Quan, FF Wang, X Lu - Tetrahedron: Asymmetry, 2011 - Elsevier
A novel asymmetric synthesis of oseltamivir phosphate 1 from the naturally abundant (−)-
shikimic acid via 3, 4-cyclic sulfite intermediate 3 (Scheme 1) is described. Target compound …
被引用次数：32 相关文章 所有 2 个版本

A novel azide-free asymmetric synthesis of oseltamivir phosphate (Tamiflu) starting from Roche's epoxide

LD Nie, FF Wang, W Ding, XX Shi, X Lu - Tetrahedron: Asymmetry, 2013 - Elsevier
A novel azide-free asymmetric synthesis of oseltamivir phosphate 1 (Tamiflu®) starting from
Roche's epoxide is described. Roche epoxide 2 was converted into N-acetyl aminoalcohol 3 …
被引用次数：20 相关文章 所有 3 个版本

Morita–Baylis–Hillman approach toward formal total synthesis of Tamiflu and total synthesis of gabaculine

S Bhowmik, S Batra - European Journal of Organic Chemistry, 2013 - Wiley Online Library
Abstract A Morita–Baylis–Hillman reaction mediated approach to the formal total synthesis of
oseltamivir and the total synthesis of gabaculine is described. This strategy involves the …
被引用次数：18 相关文章 所有 5 个版本
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Applications of tethered asymmetric hydrogenation catalysts

TH Hall - 2017 - wrap.warwick.ac.uk
Attempts have been made to prepare new polymer supported and maleimide functionalised
ruthenium catalysts for asymmetric transfer hydrogenation. Synthetic approaches were …
相关文章 所有 4 个版本