Liquid–liquid phase separation and its mechanistic role in pathological protein aggregation
WM Babinchak, WK Surewicz - Journal of molecular biology, 2020 - Elsevier
Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less
organelles. While it has been recognized for some time that these organelles are of key …
organelles. While it has been recognized for some time that these organelles are of key …
Multicomponent peptide assemblies
DM Raymond, BL Nilsson - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …
materials for applications in biomedicine and energy. The emergent properties of these …
[HTML][HTML] Application of differential scanning calorimetry (DSC) and modulated differential scanning calorimetry (MDSC) in food and drug industries
Phase transition issues in the field of foods and drugs have significantly influenced these
industries and consequently attracted the attention of scientists and engineers. The study of …
industries and consequently attracted the attention of scientists and engineers. The study of …
Differential scanning calorimetry as a tool for protein folding and stability
CM Johnson - Archives of biochemistry and biophysics, 2013 - Elsevier
Differential scanning calorimetry measures the heat capacity of states and the excess heat
associated with transitions that can be induced by temperature change. The integral of the …
associated with transitions that can be induced by temperature change. The integral of the …
[HTML][HTML] Stability matters, too–the thermodynamics of amyloid fibril formation
AK Buell - Chemical Science, 2022 - pubs.rsc.org
Amyloid fibrils are supramolecular homopolymers of proteins that play important roles in
biological functions and disease. These objects have received an exponential increase in …
biological functions and disease. These objects have received an exponential increase in …
[HTML][HTML] Targeting amyloid aggregation: an overview of strategies and mechanisms
Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …
Regulatory function of buckwheat‐resistant starch supplementation on lipid profile and gut microbiota in mice fed with a high‐fat diet
Y Zhou, S Zhao, Y Jiang, Y Wei… - Journal of food …, 2019 - Wiley Online Library
Buckwheat‐resistant starch (BRS) has shown to be a nutrient capable of lowering
cholesterol and reducing obesity. In this study, the regulatory effects of tartary buckwheat …
cholesterol and reducing obesity. In this study, the regulatory effects of tartary buckwheat …
Inhibiting, promoting, and preserving stability of functional protein fibrils
OG Jones, R Mezzenga - Soft Matter, 2012 - pubs.rsc.org
Protein fibrils are relevant not only in medicine and amyloid-related neurodegenerative
diseases, but also as functional structures in material science or biology. The assembly of …
diseases, but also as functional structures in material science or biology. The assembly of …
[HTML][HTML] Higher and lower supramolecular orders for the design of self-assembled heterochiral tripeptide hydrogel biomaterials
S Marchesan, KE Styan, CD Easton… - Journal of materials …, 2015 - pubs.rsc.org
The self-assembly behaviour of the eight stereoisomers of Val–Phe–Phe tripeptides under
physiological conditions is assessed by several spectroscopy and microscopy techniques …
physiological conditions is assessed by several spectroscopy and microscopy techniques …
[PDF][PDF] Environmental conditions affect the kinetics of nucleation of amyloid fibrils and determine their morphology
B Morel, L Varela, AI Azuaga, F Conejero-Lara - Biophysical journal, 2010 - cell.com
To understand and tackle amyloid-related diseases, it is crucial to investigate the factors that
modulate amyloid formation of proteins. Our previous studies proved that the N47A mutant of …
modulate amyloid formation of proteins. Our previous studies proved that the N47A mutant of …