The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …

One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Ferroptosis is an iron-and lipid reactive oxygen species (ROS)-dependent form of
programmed cell death that is distinct from other forms of regulatory cell death at the …