The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

Unique intercellular junctional complexes between the central nervous system (CNS)
microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial …

Neutrophils and macrophages, as key mediators of inflammation, have defined functionally
important roles in mammalian tissue repair. Although recent evidence suggests that similar …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

The blood–brain barrier (BBB) is essential for maintaining homeostasis within the central
nervous system (CNS) and is a prerequisite for proper neuronal function. The BBB is …

Paracrine Wnt/β-catenin signalling is important during developmental processes, tissue
regeneration and stem cell regulation. Wnt proteins are morphogens, which form …

A regular heartbeat is essential to vertebrate life. In the mature heart, this function is driven
by an anatomically localized pacemaker. By contrast, pacemaking capability is broadly …

How cells acquire their fate is a fundamental question in developmental and regenerative
biology. Multipotent progenitors undergo cell-fate restriction in response to cues from the …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …