Cancer is the main cause of death worldwide and metastasis is a major cause of poor
prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a …

High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …

Changes in metabolism of macrophages are required to sustain macrophage activation in
response to different stimuli. We showed that the cytokine TGF-β (transforming growth factor …

Rationale: In the glioblastoma (GBM) microenvironment, tumor-associated macrophages
(TAMs) are prominent components and facilitate tumor growth. The exact molecular …

The tumor microenvironment evolves during malignant progression, with major changes in
nonmalignant cells, cytokine networks, and the extracellular matrix (ECM). In this study, we …

A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the
extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites …

Background Ovarian cancer causes more than 15000 deaths per year in the United States.
The survival of patients is quite heterogeneous, and accurate prognostic tools would help …

The secreted extracellular protein, transforming growth factor beta induced (TGFBI or
βIGH3), has roles in regulating numerous biological functions, including cell adhesion and …

Ovarian cancer is the most common type of gynecologic cancer. One of the leading causes
of high mortality is chemoresistance, developed primarily or during treatment. Different …

Abstract Tumor-associated macrophages (TAMs), as a major and essential component of
tumor microenvironment (TME), play a critical role in orchestrating pancreatic cancer (PaC) …