Social isolation and the brain: effects and mechanisms

Y Xiong, H Hong, C Liu, YQ Zhang - Molecular psychiatry, 2023 - nature.com
An obvious consequence of the coronavirus disease (COVID-19) pandemic is the worldwide
reduction in social interaction, which is associated with many adverse effects on health in …

Detection, processing and reinforcement of social cues: regulation by the oxytocin system

R Menon, ID Neumann - Nature Reviews Neuroscience, 2023 - nature.com
Many social behaviours are evolutionarily conserved and are essential for the healthy
development of an individual. The neuropeptide oxytocin (OXT) is crucial for the fine-tuned …

Neurobiology of loneliness, isolation, and loss: integrating human and animal perspectives

EM Vitale, AS Smith - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
In social species such as humans, non-human primates, and even many rodent species,
social interaction and the maintenance of social bonds are necessary for mental and …

Neural circuits regulating prosocial behaviors

JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

Dynamic influences on the neural encoding of social valence

N Padilla-Coreano, KM Tye… - Nature Reviews …, 2022 - nature.com
Social signals can serve as potent emotional triggers with powerful impacts on processes
from cognition to valence processing. How are social signals dynamically and flexibly …

[HTML][HTML] Advancing social behavioral neuroscience by integrating ethology and comparative psychology methods through machine learning

J Bordes, L Miranda, B Müller-Myhsok… - … & Biobehavioral Reviews, 2023 - Elsevier
Social behavior is naturally occurring in vertebrate species, which holds a strong
evolutionary component and is crucial for the normal development and survival of …

Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats

H Nishimura, M Yoshimura, M Shimizu… - Communications …, 2022 - nature.com
Oxytocin is involved in pain transmission, although the detailed mechanism is not fully
understood. Here, we generate a transgenic rat line that expresses human muscarinic …

Social isolation shortens lifespan through oxidative stress in ants

A Koto, M Tamura, PS Wong, S Aburatani… - Nature …, 2023 - nature.com
Social isolation negatively affects health, induces detrimental behaviors, and shortens
lifespan in social species. Little is known about the mechanisms underpinning these effects …

Environmental enrichment and social isolation modulate inhibitory transmission and plasticity in hippocampal area CA2

M Loisy, A Farah, A Fafouri, A Fanton, M Ahmadi… - …, 2023 - Wiley Online Library
Environmental factors are well‐accepted to play a complex and interdependent role with
genetic factors in learning and memory. The goal of this study was to examine how …

Convergence of oxytocin and dopamine signaling in neuronal circuits: Insights into the neurobiology of social interactions across species

V Rappeneau, F Castillo-Díaz - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
Social behaviours are essential for animal survival, and the hypothalamic neuropeptide
oxytocin (OXT) critically impacts bonding, parenting, and decision-making. Dopamine (DA) …