Thiazole-containing compounds as therapeutic targets for cancer therapy

PC Sharma, KK Bansal, A Sharma, D Sharma… - European journal of …, 2020 - Elsevier
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery

SR Alizadeh, SM Hashemi - Medicinal Chemistry Research, 2021 - Springer
Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

Synthesis and molecular docking of some novel 3-thiazolyl-coumarins as inhibitors of VEGFR-2 kinase

TZ Abolibda, M Fathalla, B Farag, MEA Zaki… - Molecules, 2023 - mdpi.com
One crucial strategy for the treatment of breast cancer involves focusing on the Vascular
Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the …

[HTML][HTML] Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

NY Guerrero-Pepinosa, MC Cardona-Trujillo… - Biomedicine & …, 2021 - Elsevier
Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

Efficient synthesis, antibacterial, antifungal, antioxidant and cytotoxicity study of 2‐(2‐hydrazineyl) thiazole derivatives

VA Adole, RA More, BS Jagdale, TB Pawar… - …, 2020 - Wiley Online Library
In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of
novel 2‐(2‐hydrazinyl) thiazole derivatives from 1, 2, 6, 7‐tetrahydro‐8H‐indeno [5, 4‐b] …

2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents

Y Wan, J Long, H Gao, Z Tang - European Journal of Medicinal Chemistry, 2021 - Elsevier
Cancer has been the second heath killer being next only to cardiovascular diseases in
human society. Although many efforts have been taken for cancer therapy and many …

Synthesis, in vitro evaluation and molecular docking studies of novel thiophenyl thiazolyl-pyridine hybrids as potential anticancer agents

FO Ashmawy, SM Gomha, MA Abdallah, MEA Zaki… - Molecules, 2023 - mdpi.com
Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives,
especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with …

Thiazole–chalcone hybrids as prospective antitubercular and antiproliferative agents: Design, synthesis, biological, molecular docking studies and in silico ADME …

AB Kasetti, I Singhvi, R Nagasuri, RR Bhandare… - Molecules, 2021 - mdpi.com
Compounds bearing thiazole and chalcone pharmacophores have been reported to
possess excellent antitubercular and anticancer activities. In view of this, we designed …

Synthesis, molecular docking and antiproliferative activity studies of a thiazole‐based compound linked to hydrazone moiety

H Kekeçmuhammed, M Tapera, B Tüzün… - …, 2022 - Wiley Online Library
Abstract (A new 4‐oxothiazolidin‐2‐ylidene derivative bearing hydrazone moiety was
synthesized via Michael addition between the reaction of 4‐(4‐nitrophenyl)‐3 …

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria

CB Scarim, DH Jornada, MGM Machado… - European journal of …, 2019 - Elsevier
Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …