Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however,
only recently has it become possible to identify the molecular events that underlie the …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide
range of anti-metabolic activities when tested against cultured cancer cells and to be an …