The canonical role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in
repairing DNA double-strand breaks combined with its reported dysregulation in several …

Protein phosphorylation is a ubiquitous post-translational modification controlled by the
opposing activities of protein kinases and phosphatases, which regulate diverse biological …

The biological role of the repetitive DNA sequences in the human genome remains an
outstanding question. Recent long-read human genome assemblies have allowed us to …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a member of the
phosphatidylinositol 3-kinase-related kinase family is a well-known player in repairing DNA …

The key DNA repair enzyme DNA-PKcs has several and important cellular functions. Loss of
DNA-PKcs activity in mice has revealed essential roles in immune and nervous systems. In …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a vital role in DNA
damage repair and lymphocyte function, presenting a significant target in cancer and …

Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-
renewal capacity and myeloid skewing. We report that culture of BM HSCs from aged mice …

Background: Maintenance of the genome is essential for cell survival, and impairment of the
DNA damage response is associated with multiple pathologies including cancer and …

The DNA‐dependent protein kinase (DNA‐PK), catalytic subunit, also known as DNA‐PKcs,
is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well …

Modulation of T cell activity is an effective strategy for the treatment of autoimmune diseases,
immune‐related disorders and cancer. This highlights a critical need for the identification of …