Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …

Naturally and synthetically derived hybrid molecules are an attractive source for therapeutic
agent development due to their dual or multiple modes of action and other advantages …

Thymidylate synthase (TS) has been an attention-grabbing area of research for the
treatment of cancers due to their role in DNA biosynthesis. In the present study, we have …

Nowadays, hybrid drugs containing two or more covalently linked known potential
pharmacophores are designed to simultaneously modulate multiple targets of multifactorial …

This study aimed to determine the in vitro cytotoxicity and understand possible cytotoxic
mechanisms via an in silico study of eleven chalcones synthesized from two …

Isatins are endogenous molecules present in human and mammals which exhibits diverse
pharmacological profiles including anticancer activity. Similarly, chalcones, which are …

Methoxy group enriched eight coumarin‐chalcone hybrid derivatives were synthesized.
Antimicrobial/antiproliferative activities were tested against eight human pathogenic …

Abstract A series of fluorinated 3, 6-diaryl-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazoles (2a–2i)
was synthesized by condensation of various substituted 4-amino-5-phenyl-4H-1, 2, 4 …

Recently, a new generation of highly promising inhibitors bearing β-keto-enol functionality
has emerged. Reported herein is the first synthesis and use of novel designed drugs based …