[HTML][HTML] Therapeutic host-directed strategies to improve outcome in tuberculosis
Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …
has limited efficacy against pulmonary TB disease development and modest protection …
Autophagy: A new strategy for host-directed therapy of tuberculosis
Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …
Role of apoptosis and autophagy in tuberculosis
A Lam, R Prabhu, CM Gross… - … of Physiology-Lung …, 2017 - journals.physiology.org
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …
Host‐directed therapy to combat mycobacterial infections
G Kilinç, A Saris, THM Ottenhoff… - Immunological …, 2021 - Wiley Online Library
Upon infection, mycobacteria, such as Mycobacterium tuberculosis (Mtb) and
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …
nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering …
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …
The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy
The major causative agent of tuberculosis (TB), ie, Mycobacterium tuberculosis (Mtb), has
developed mechanisms to evade host defense responses and persist within host cells for …
developed mechanisms to evade host defense responses and persist within host cells for …
Innate immune responses in leprosy
Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …
immune response to Mycobacterium leprae. Several studies have clarified the role of …
Targeting molecular inflammatory pathways in granuloma as host-directed therapies for tuberculosis
Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million
deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the …
deaths in 2020. In addition, the emergence of drug-resistant strains in many regions of the …
Autophagy-activating strategies to promote innate defense against mycobacteria
Mycobacterium tuberculosis (Mtb) is a major causal pathogen of human tuberculosis (TB),
which is a serious health burden worldwide. The demand for the development of an …
which is a serious health burden worldwide. The demand for the development of an …
Exploring the drug repurposing versatility of valproic acid as a multifunctional regulator of innate and adaptive immune cells
R Soria-Castro, A Schcolnik-Cabrera… - Journal of …, 2019 - Wiley Online Library
Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other
neurological disorders in the past 50 years. Recent evidence has shown the potential of …
neurological disorders in the past 50 years. Recent evidence has shown the potential of …