The NME family of proteins is composed of 10 isoforms, designated NME1-10, which are
diverse in their enzymatic activities and patterns of subcellular localization. Each contains a …

The innate immune response depends on the ability of immune cells to detect pathogens
through germline-encoded pattern recognition receptors (PRRs). Recently discovered PRRs …

Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular
DNA, modulates various cell functions, however, its role in regulating virus growth remains …

The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA,
initiating innate immune signaling and suppressing viral transcription. However, little is …

ABSTRACT IFI16 (interferon gamma-inducible protein 16) recognizes nuclear episomal
herpesvirus (Kaposi's sarcoma-associated herpesvirus [KSHV], Epstein-Barr virus [EBV] …

The innate immune system defenses against pathogen infections via patten-recognition
receptors (PRRs). PRRs initiate immune responses by recognizing pathogen-associated …

Interferon-inducible protein 16 (IFI16) is a member of the HIN-200 protein family, containing
two HIN domains and one PYRIN domain. IFI16 acts as a sensor of viral and bacterial DNA …

Interferon (IFN)-inducible HIN-200 proteins play an important role in transcriptional
regulation linked to cell cycle control, inflammation, autoimmunity and differentiation. IFI16 …

Innate immune sensors and restriction factors are cellular proteins that synergize to build an
effective first line of defense against viral infections. Innate sensors are usually constitutively …

The oligonucleotide/oligosaccharide binding (OB) fold is employed by proteins to bind
nucleic acids during replication, transcription, and translation. Recently, a variation of the OB …