Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging cancers to
treat. For patients with advanced and metastatic disease, chemotherapy has yielded only …

Immune checkpoint inhibitors have reshaped the prognostic of several tumor types,
including metastatic colorectal tumors with microsatellite instability (MSI). However, 90-95 …

Treatment options for molecular subtypes of endometrial canc... : Current Opinion in Obstetrics
and Gynecology Treatment options for molecular subtypes of endometrial cancer in 2023 …

Kirsten rat sarcoma virus (KRAS)–G12C inhibition causes remodeling of the lung tumor
immune microenvironment and synergistic responses to anti–PD-1 treatment, but only in T …

This article reviews treatments and targets of interest in endometrial cancer by molecular
subtype. The Cancer Genome Atlas (TCGA) classifies four molecular subtypes—mismatch …

Background Glioblastoma is a highly aggressive brain cancer that is resistant to
conventional immunotherapy strategies. Botensilimab, an Fc-enhanced anti-CTLA-4 …

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy, with poor
survival rates among patients who have advanced disease despite recent significant …

For twelve years, the oncology field has been revolutionized by antibodies targeting immune
checkpoints. They must be considered as a heterogenous family of immunostimulatory …

Background Cancer cells activate different immune checkpoint (IC) pathways in order to
evade immunosurveillance. Immunotherapies involving ICs either block or stimulate these …

Background Microsatellite stable (MSS) metastatic colorectal cancer (CRC) remains
predominantly managed with chemotherapy. The use of immunotherapy, whether alone or …