Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
The compendium of self-enactable techniques to change and self-manage motivation and behaviour v. 1.0
Behaviour change techniques describe the content of behaviour change interventions, but
do not adequately account for the actions that people must themselves undertake to …
do not adequately account for the actions that people must themselves undertake to …
The architecture of Talin1 reveals an autoinhibition mechanism
D Dedden, S Schumacher, CF Kelley, M Zacharias… - Cell, 2019 - cell.com
Focal adhesions (FAs) are protein machineries essential for cell adhesion, migration, and
differentiation. Talin is an integrin-activating and tension-sensing FA component directly …
differentiation. Talin is an integrin-activating and tension-sensing FA component directly …
PI(4,5)P2: signaling the plasma membrane
RC Wills, GRV Hammond - Biochemical Journal, 2022 - portlandpress.com
In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …
CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis
JM Peng, SH Lin, MC Yu… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Membrane protrusion and adhesion to the extracellular matrix, which involves the extension
of actin filaments and formation of adhesion complexes, are the fundamental processes for …
of actin filaments and formation of adhesion complexes, are the fundamental processes for …
A perspective: active role of lipids in neurotransmitter dynamics
PA Postila, T Róg - Molecular Neurobiology, 2020 - Springer
Synaptic neurotransmission is generally considered as a function of membrane-embedded
receptors and ion channels in response to the neurotransmitter (NT) release and binding …
receptors and ion channels in response to the neurotransmitter (NT) release and binding …
Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …
context of the role that the lipid membrane can play in drug action, ie, the interaction …