Barriers to clinical adoption of pharmacogenomic testing in psychiatry: a critical analysis

CR Virelli, AG Mohiuddin, JL Kennedy - Translational psychiatry, 2021 - nature.com
Pharmacogenomics (PGx) is the study of genetic influences on an individual's response to
medications. Improvements in the quality and quantity of PGx research over the past two …

Challenges and future prospects of precision medicine in psychiatry

M Manchia, C Pisanu, A Squassina… - Pharmacogenomics …, 2020 - Taylor & Francis
Precision medicine is increasingly recognized as a promising approach to improve disease
treatment, taking into consideration the individual clinical and biological characteristics …

Clinical utility of combinatorial pharmacogenomic testing in depression: A Canadian patient-and rater-blinded, randomized, controlled trial

AK Tiwari, CC Zai, CA Altar, JA Tanner… - Translational …, 2022 - nature.com
The pharmacological treatment of depression consists of stages of trial and error, with less
than 40% of patients achieving remission during first medication trial. However, in a large …

Pharmacogenomics at the point of care: a community pharmacy project in British Columbia

S Breaux, FAD Desrosiers, M Neira, S Sinha… - Journal of Personalized …, 2020 - mdpi.com
In this study 180 patients were consented and enrolled for pharmacogenomic testing based
on current antidepressant/antipsychotic usage. Samples from patients were genotyped by …

Clinical implications of combinatorial pharmacogenomic tests based on cytochrome P450 variant selection

M Sayer, A Duche, TJT Nguyen, M Le, K Patel… - Frontiers in …, 2021 - frontiersin.org
Despite the potential to improve patient outcomes, the application of pharmacogenomics
(PGx) is yet to be routine. A growing number of PGx implementers are leaning toward using …

Individualized medication management in Ontario long-term care clinical impact on management of depression, pain, and dementia

R Dorfman, Z London, M Metias, B Kabakchiev… - Journal of the American …, 2020 - Elsevier
Objectives Assess the potential benefits of identifying drug-gene interactions in nursing
home (NH) residents on multiple medications. Reduce the use of high-risk medications for …

Analyzing precision medicine utilization with real-world data: a scoping review

MP Douglas, A Kumar - Journal of Personalized Medicine, 2022 - mdpi.com
Precision medicine (PM), specifically genetic-based testing, is currently used in over
140,000 individual tests to inform the clinical management of disease. Though several …

[HTML][HTML] Normalising the Implementation of Pharmacogenomic (PGx) Testing in Adult Mental Health Settings: A Theory-Based Systematic Review

A Jameson, J Tomlinson… - Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Pharmacogenomic (PGx) testing can help personalise psychiatric prescribing and improve
on the currently adopted trial-and-error prescribing approach. However, widespread …

The Utility of CYP2D6 and CYP2C19 Variants to Guide Pharmacological Treatment in Complex Unipolar Major Depression: A Pilot Longitudinal Study

R Ramaraj, ZN Al-Mahayri, R Saleous, K Abdel Aziz… - Psychiatric …, 2023 - Springer
Major depression is a frequent condition which variably responds to treatment. In view of its
high prevalence, the presence of treatment resistance in major depression significantly …

Application of Informatics Tools to Facilitate the Practice of Precision Medicine with Genomic Testing and Clinical Data

MR Sayer - 2023 - search.proquest.com
The practice of precision medicine considers a variety of sources of information to optimize
patient care. Factors such as patient demographics, clinical history, and lab test values have …