Improving lateral flow assay performance using computational modeling

D Gasperino, T Baughman, HV Hsieh… - Annual review of …, 2018 - annualreviews.org
The performance, field utility, and low cost of lateral flow assays (LFAs) have driven a
tremendous shift in global health care practices by enabling diagnostic testing in previously …

The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore

B Goldstein, D Coombs, X He… - Journal of molecular …, 1999 - Wiley Online Library
Accurate estimation of biomolecular reaction rates from binding data, when ligands in
solution bind to receptors on the surfaces of cells or biosensors, requires an understanding …

[HTML][HTML] Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting

SL Veatch, BB Machta, SA Shelby, EN Chiang… - PloS one, 2012 - journals.plos.org
We present an analytical method using correlation functions to quantify clustering in super-
resolution fluorescence localization images and electron microscopy images of static …

Biophysical and biochemical aspects of fluorescence spectroscopy

TG Dewey - 1991 - Springer
Fluorescence spectroscopy has traditionally found wide application in biochemistry and cell
biology. Since there are relatively few naturally occurring fluorescent biomolecules …

Effects of clustered epitopes in multivalent ligand− receptor interactions

TK Dam, CF Brewer - Biochemistry, 2008 - ACS Publications
Many biological ligands are composed of clustered binding epitopes. However, the effects of
clustered epitopes on the affinity of ligand− receptor interactions in many cases are not well …

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

HS Wiley - The Journal of cell biology, 1988 - rupress.org
This study was conducted to determine how extraordinarily high numbers of epidermal
growth factor receptors (EGF-R) affected the binding and internalization of EGF in the …

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.

RL Macdonald, CJ Rogers… - The Journal of …, 1989 - Wiley Online Library
1. The kinetic properties of the main conductance state of gamma‐aminobutyric acidA
(GABA) receptor channels from somata of mouse spinal cord neurones in cell culture were …

Rule‐based modeling of biochemical networks

JR Faeder, ML Blinov, B Goldstein, WS Hlavacek - Complexity, 2005 - Wiley Online Library
We present a method for generating a biochemical reaction network from a description of the
interactions of components of biomolecules. The interactions are specified in the form of …

[HTML][HTML] Impact of receptor clustering on ligand binding

BR Caré, HA Soula - BMC Systems Biology, 2011 - Springer
Background Cellular response to changes in the concentration of different chemical species
in the extracellular medium is induced by ligand binding to dedicated transmembrane …

Modeling for (physical) biologists: an introduction to the rule-based approach

LA Chylek, LA Harris, JR Faeder… - Physical biology, 2015 - iopscience.iop.org
Abstract Models that capture the chemical kinetics of cellular regulatory networks can be
specified in terms of rules for biomolecular interactions. A rule defines a generalized …