Improving lateral flow assay performance using computational modeling
D Gasperino, T Baughman, HV Hsieh… - Annual review of …, 2018 - annualreviews.org
The performance, field utility, and low cost of lateral flow assays (LFAs) have driven a
tremendous shift in global health care practices by enabling diagnostic testing in previously …
tremendous shift in global health care practices by enabling diagnostic testing in previously …
The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore
B Goldstein, D Coombs, X He… - Journal of molecular …, 1999 - Wiley Online Library
Accurate estimation of biomolecular reaction rates from binding data, when ligands in
solution bind to receptors on the surfaces of cells or biosensors, requires an understanding …
solution bind to receptors on the surfaces of cells or biosensors, requires an understanding …
[HTML][HTML] Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting
We present an analytical method using correlation functions to quantify clustering in super-
resolution fluorescence localization images and electron microscopy images of static …
resolution fluorescence localization images and electron microscopy images of static …
Biophysical and biochemical aspects of fluorescence spectroscopy
TG Dewey - 1991 - Springer
Fluorescence spectroscopy has traditionally found wide application in biochemistry and cell
biology. Since there are relatively few naturally occurring fluorescent biomolecules …
biology. Since there are relatively few naturally occurring fluorescent biomolecules …
Effects of clustered epitopes in multivalent ligand− receptor interactions
TK Dam, CF Brewer - Biochemistry, 2008 - ACS Publications
Many biological ligands are composed of clustered binding epitopes. However, the effects of
clustered epitopes on the affinity of ligand− receptor interactions in many cases are not well …
clustered epitopes on the affinity of ligand− receptor interactions in many cases are not well …
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.
HS Wiley - The Journal of cell biology, 1988 - rupress.org
This study was conducted to determine how extraordinarily high numbers of epidermal
growth factor receptors (EGF-R) affected the binding and internalization of EGF in the …
growth factor receptors (EGF-R) affected the binding and internalization of EGF in the …
Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.
RL Macdonald, CJ Rogers… - The Journal of …, 1989 - Wiley Online Library
1. The kinetic properties of the main conductance state of gamma‐aminobutyric acidA
(GABA) receptor channels from somata of mouse spinal cord neurones in cell culture were …
(GABA) receptor channels from somata of mouse spinal cord neurones in cell culture were …
Rule‐based modeling of biochemical networks
We present a method for generating a biochemical reaction network from a description of the
interactions of components of biomolecules. The interactions are specified in the form of …
interactions of components of biomolecules. The interactions are specified in the form of …
[HTML][HTML] Impact of receptor clustering on ligand binding
Background Cellular response to changes in the concentration of different chemical species
in the extracellular medium is induced by ligand binding to dedicated transmembrane …
in the extracellular medium is induced by ligand binding to dedicated transmembrane …
Modeling for (physical) biologists: an introduction to the rule-based approach
Abstract Models that capture the chemical kinetics of cellular regulatory networks can be
specified in terms of rules for biomolecular interactions. A rule defines a generalized …
specified in terms of rules for biomolecular interactions. A rule defines a generalized …