Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Acute kidney injury (AKI) is attended by injury-related biomarkers appearing in the urine and
serum, decreased urine output, and impaired glomerular filtration rate. AKI causes increased …

The incidence of kidney disease is rising, constituting a significant burden on the healthcare
system and making identification of new therapeutic targets increasingly urgent. The heme …

Studies of genetic variants and their associations with disease outcomes using recent
molecular technology advances and the broad variety of statistical methodologies available …

Background: Sickle cell trait affects∼ 8% of African American individuals, along with many
other individuals with ancestry from malaria-endemic regions worldwide. While traditionally …

To address the global burden of sickle cell disease and the need for novel therapies, the
American Society of Hematology partnered with the US Food and Drug Administration to …

Background Mechanisms underlying ischemia/reperfusion injury-acute kidney injury (IRI-
AKI) are not fully elucidated. We conducted an integrative analysis of IRI-AKI by …

Introduction Heme-oxygenase 1 (HMOX1) is a critical stress response gene that catalyzes
the multistep oxidation of heme. A GT (n) repeat of variable length in the promoter in has …

Background People with sickle cell disease (SCD) have an elevated estimated glomerular
filtration rate (eGFR) compared with the general population, and this may alter the usual …