New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases

H Nam, JS An, J Lee, Y Yun, H Lee… - Journal of the …, 2023 - ACS Publications
Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …

Enzymatic carbon–sulfur bond formation in natural product biosynthesis

KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

[HTML][HTML] Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Biologically active secondary metabolites from the fungi

GF Bills, JB Gloer - Microbiology spectrum, 2016 - Am Soc Microbiol
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …

P450-modified ribosomally synthesized peptides with aromatic cross-links

YL Hu, FZ Yin, J Shi, SY Ma, ZR Wang… - Journal of the …, 2023 - ACS Publications
Cyclization of linear peptides is an effective strategy to convert flexible molecules into rigid
compounds, which is of great significance for enhancing the peptide stability and bioactivity …

Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases

DN Chigumba, LS Mydy, F de Waal, W Li… - Nature Chemical …, 2022 - nature.com
Many bioactive plant cyclic peptides form side-chain-derived macrocycles. Lyciumins, cyclic
plant peptides with tryptophan macrocyclizations, are ribosomal peptides (RiPPs) originating …

Progress and perspectives on directing group-assisted palladium-catalysed C–H functionalisation of amino acids and peptides

S Shabani, Y Wu, HG Ryan, CA Hutton - Chemical Society Reviews, 2021 - pubs.rsc.org
Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …