Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Alcohol abuse disorder is a serious condition, implicating more than 15 million people aged
12 years and older in 2019 in the United States. Ethanol (or ethyl alcohol) is mainly oxidized …

Brain imaging technology has allowed researchers to conduct rigorous studies of the
dynamic course of alcoholism through periods of drinking, sobriety, and relapse and to gain …

NADPH oxidases (NOXs) are involved in inflammation, angiogenesis, tumor growth, and
osteoclast differentiation. However, the role of NOX1 and NOX2 in macrophage …

Drinking alcohol, even in moderation, can affect the immune system. Studies have shown
disproportionate effects of alcohol on circulating and tissue-resident myeloid cells …

It has long been known that people with alcohol use disorder (AUD) not only may develop
physical dependence but also may experience devastating long-term health problems. The …

Globally, an estimated 107 million people have an alcohol use disorder (AUD) leading to 2.8
million premature deaths each year. Tuberculosis (TB) is one of the leading causes of death …

Macrophages play an essential role in alcohol-induced inflammation and oxidative stress.
We investigated the effects of nicotinamide riboside (NR), a natural nicotinamide adenine …

Significance: The evolution of the lungs and circulatory systems in vertebrates ensured the
availability of molecular oxygen (O2; dioxygen) for aerobic cellular metabolism of internal …

The brain is one of the major targets of alcohol actions. Most of the excitatory synaptic
transmission in the central nervous system is mediated by N-methyl-D-aspartate (NMDA) …