The expression of a foreign protein (s) in a recombinant host cell or organism often utilizes a
significant amount of the host cell's resources, removing those resources away from host cell …

In the context of recombinant DNA technology, the development of feasible and high-
yielding plasmid DNA production processes has regained attention as more evidence for its …

A transition toward sustainable bio-based chemical production is important for green growth.
However, productivity and yield frequently decrease as large-scale microbial fermentation …

Strong production of recombinant proteins interferes with cellular processes in many ways.
Drainage of precursors and energy urges the cell to readjust metabolic fluxes and enzyme …

Gene therapy is a promising process for the prevention, treatment and cure of diseases such
as cancer, acquired immunodeficiency syndrome (AIDS) and cystic fibrosis. One of the …

Virulence functions of pathogenic bacteria are often encoded on large extrachromosomal
plasmids. These plasmids are maintained at low copy number to reduce the metabolic …

Background Molecular mechanisms generating genetic variation provide the basis for
evolution and long-term survival of a population in a changing environment. In stable …

Background L-cysteine is an essential chemical building block in the pharmaceutical-,
cosmetic-, food and agricultural sector. Conventionally, L-cysteine production relies on the …

Synthetic genetic programs promise to enable novel applications in industrial processes. For
such applications, the genetic circuits that compose programs will require fidelity in varying …

There are many aims associated with the optimization of fermentation processes.
Optimization is expected to increase the yield of the final product but the process must be …