Biomechanical performance of functional cartilage is executed by the exclusive anisotropic
composition and spatially varying intricate architecture in articulating ends of diarthrodial …

Glycosaminoglycans (GAGs) are an untapped source of novel chemical entities and,
therefore, offer exciting new opportunities for the development of novel drug molecules …

Biomaterials have had a major impact on the practice of contemporary medicine and patient
care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers …

Although glycosaminoglycans constitute a minor portion of native tissues, they play a crucial
role in various physiological processes, while their abnormal expression is associated with …

In a previous study, we showed that in situ injection of glycosaminoglycan mimetics called
RGTAs®(ReGeneraTing Agents) enhanced neovascularization after skeletal muscular …

Skeletal muscle regeneration occurs by the activation, proliferation and fusion of muscle
precursor cells (myoblasts) that usually lie in a satellite cell position on the surface of the …

The causes of Parkinson disease (PD) remain mysterious, although some evidence
supports mitochondrial dysfunctions and α-synuclein accumulation in Lewy bodies as major …

Herein we investigate the structure/function relationships of fucoidans from Ascophyllum
nodosum to analyze their pro-angiogenic effect and cellular uptake in native and …

Cell surface heparan sulfate (HS) proteoglycans are carbohydrate-rich regulators of cell
migratory, mitogenic, secretory, and inflammatory activity that bind and present soluble …

The CC-chemokine regulated on activation, normal T-cell expressed, and presumably
secreted (RANTES)/CCL5 mediates its biological activities through activation of G protein …