The tubulin code in microtubule dynamics and information encoding

A Roll-Mecak - Developmental cell, 2020 - cell.com
Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Causes and consequences of microtubule acetylation

C Janke, G Montagnac - Current Biology, 2017 - cell.com
Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 …

Tubulin post-translational modifications and microtubule dynamics

D Wloga, E Joachimiak, H Fabczak - International journal of molecular …, 2017 - mdpi.com
Microtubules are hollow tube-like polymeric structures composed of α, β-tubulin
heterodimers. They play an important role in numerous cellular processes, including …

Microtubule acetylation dyshomeostasis in Parkinson's disease

P Naren, KS Samim, KP Tryphena, LK Vora… - Translational …, 2023 - Springer
The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Tubulin post-translational modifications: the elusive roles of acetylation

B Carmona, HS Marinho, CL Matos, S Nolasco… - Biology, 2023 - mdpi.com
Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Intrinsic and extrinsic factors affecting microtubule dynamics in normal and cancer cells

F Borys, E Joachimiak, H Krawczyk, H Fabczak - Molecules, 2020 - mdpi.com
Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals

HAJ Saunders, DM Johnson-Schlitz, BV Jenkins… - Current Biology, 2022 - cell.com
Microtubules are essential to neuron shape and function. Acetylation of tubulin has the
potential to directly tune the behavior and function of microtubules in cells. Although …

[HTML][HTML] Tubulins and brain development–The origins of functional specification

MW Breuss, I Leca, T Gstrein, AH Hansen… - Molecular and Cellular …, 2017 - Elsevier
The development of the vertebrate central nervous system is reliant on a complex cascade
of biological processes that include mitotic division, relocation of migrating neurons, and the …

FICD activity and AMPylation remodelling modulate human neurogenesis

P Kielkowski, IY Buchsbaum, VC Kirsch… - Nature …, 2020 - nature.com
Posttranslational modification (PTM) of proteins represents an important cellular mechanism
for controlling diverse functions such as signalling, localisation or protein–protein …

Posttranslational modifications of the cytoskeleton

B MacTaggart, A Kashina - Cytoskeleton, 2021 - Wiley Online Library
The cytoskeleton plays important roles in many essential processes at the cellular and
organismal levels, including cell migration and motility, cell division, and the establishment …