RAS mutation is the most frequent oncogenic alteration in human cancers. KRAS is the most
frequently mutated followed by NRAS. The emblematic KRAS mutant cancers are …

High inter-patient variability and high spatial heterogeneity are features of colorectal cancer
(CRC). This may influence the molecular characterization of tumor tissue, now mandatory for …

Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies,
even when guided by genomic biomarkers, have had limited efficacy. A potential reason for …

Importance BRAFmutations are reportedly associated with aggressive tumor biology.
However, in contrast with primary colorectal cancer, the association of V600E and non …

Circulating tumor cells are tumor cells with high vitality and high metastatic potential that
invade and shed into the peripheral blood from primary solid tumors or metastatic foci. Due …

Tumour heterogeneity refers to the fact that different tumour cells can show distinct
morphological and phenotypic profiles, including cellular morphology, gene expression …

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and
30% of patients with CRC experience metastasis. Patients with metastatic colorectal cancer …

Cancers are the group of diseases, which arise because of the uncontrolled behavior of
some of the genes in our cells. There are possibilities of gene amplifications …

Background The use of biomarkers to target anti-EGFR treatments for metastatic colorectal
cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic …

In the last two decades, great efforts have been made in the treatment of metastatic
colorectal cancer (mCRC) due to the approval of new target agents for cytotoxic drugs …