The growing demand for green and sustainable production of high-value chemicals has
driven the interest in microbial chassis. Recent advances in synthetic biology and metabolic …

Endophytic fungi are emerging as attractive producers of natural products with diverse
bioactivities and novel structures. However, difficulties in the genetic manipulation of …

Didymorenloid A (1), a polycyclic cyclopenta [b] fluorene-type alkaloid with a new skeleton,
and one new analogue didymorenloid B (2) were isolated from the mangrove endophytic …

Perpyrrospirone A (1) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold
with a unique peroxide-bridged 8, 9-dioxa-2-azaspiro [4.7] dodecane core from marine …

Fungal paracyclophane-decahydrofluorene-containing natural products are complex
polycyclic metabolites derived from similar hybrid PKS-NRPS pathways. Herein we studied …

Tyrosine-decahydrofluorene derivatives are a class of hybrid compounds that integrate the
properties of polyketides and nonribosomal peptides. These compounds feature a [6.5. 6] …

New-to-Nature biocatalysis has emerged as a promising tool in organic synthesis thanks to
progress in protein engineering. Notably, hemeproteins have been evolved into robust …

Genotyping by sequencing (GBS) was used to reveal the inherent genetic variation within
the haploid fungi Sarocladium zeae isolated from diverse Zea germplasm, including modern …

Five novel tyrosine-decahydrofluorene analogues, xenoacremones D–H (1–5), each
bearing a fused 6/5/6 tricarbocyclic core and a 13-membered para-cyclophane ring system …

Endophytic microorganisms often play a role in the defense of their host plant by producing
metabolites with antifungal or antibiotic activities. This is the case of the maize endophytic …