Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin
cytoskeleton. Cells modify focal adhesions in response to changes in the molecular …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Focal adhesions (FAs) regulate cell migration. Vinculin, with its many potential binding
partners, can interconnect signals in FAs. Despite the well-characterized structure of …

Currently> 50 proteins have been reported to be associated with focal contacts and related
ECM adhesions. Most of these contain multiple domains through which they can interact …

We have found that epithelial cells engage in a process of cadherin-mediated intercellular
adhesion that utilizes calcium and actin polymerization in unexpected ways. Calcium …

▪ Abstract Phosphoinositides [PPIs, which collectively refer to phosphorylated derivatives of
phosphatidylinositol (PI)] have a pivotal role as precursors to important second messengers …

Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for
both cell–cell and cell–extracellular matrix (focal adhesion) adherens-type junctions, but its …

Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more
than 15 proteins. Biochemical and structural analyses have contributed to detailed …

Cellular contacts with the extracellular matrix are regulated by the Rho family of GTPases
through their effects on both the actin and the microtubule cytoarchitecture. Recent genetic …

Cell migration involves many steps, including membrane protrusion and the development of
new adhesions. Here we have investigated whether there is a link between actin …