Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

The neuroethics of disorders of consciousness: a brief history of evolving ideas

MJ Young, YG Bodien, JT Giacino, JJ Fins, RD Truog… - Brain, 2021 - academic.oup.com
Neuroethical questions raised by recent advances in the diagnosis and treatment of
disorders of consciousness are rapidly expanding, increasingly relevant and yet …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Measuring consciousness in the intensive care unit

BL Edlow, M Fecchio, YG Bodien, A Comanducci… - Neurocritical Care, 2023 - Springer
Early reemergence of consciousness predicts long-term functional recovery for patients with
severe brain injury. However, tools to reliably detect consciousness in the intensive care unit …

Proceedings of the first curing coma campaign NIH symposium: challenging the future of research for coma and disorders of consciousness

J Claassen, Y Akbari, S Alexander, MK Bader, K Bell… - Neurocritical care, 2021 - Springer
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden
for patients, families, and society worldwide. As part of the Curing Coma Campaign, the …

The curing coma campaign international survey on coma epidemiology, evaluation, and therapy (COME TOGETHER)

R Helbok, V Rass, E Beghi, YG Bodien, G Citerio… - Neurocritical Care, 2022 - Springer
Background Although coma is commonly encountered in critical care, worldwide variability
exists in diagnosis and management practices. We aimed to assess variability in coma …

A precision medicine framework for classifying patients with disorders of consciousness: Advanced Classification of Consciousness Endotypes (ACCESS)

D Kondziella, DK Menon, R Helbok, L Naccache… - Neurocritical Care, 2021 - Springer
Background Consciousness in patients with brain injury is traditionally assessed based on
semiological evaluation at the bedside. This classification is limited because of low …

Incidence and prevalence of coma in the UK and the USA

D Kondziella, M Amiri, MH Othman, E Beghi… - Brain …, 2022 - academic.oup.com
The epidemiology of coma is unknown because case ascertainment with traditional methods
is difficult. Here, we used crowdsourcing methodology to estimate the incidence and …

Proceedings of the second curing coma campaign NIH symposium: challenging the future of research for coma and disorders of consciousness

S Mainali, V Aiyagari, S Alexander, Y Bodien… - Neurocritical care, 2022 - Springer
This proceedings article presents actionable research targets on the basis of the
presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) …

A meta-analysis of dynamic prevalence of cognitive deficits in the acute, subacute, and chronic phases after traumatic brain injury

YC Tsai, CJ Liu, HC Huang, JH Lin… - Journal of …, 2021 - journals.lww.com
BACKGROUND: Reports regarding prevalence of post–traumatic brain injury (TBI) cognitive
deficits were inconsistent. We aimed to synthesize the prevalence of cognitive deficits after …