Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due
to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK …

Microcystins (MCs) are the most common cyanobacteria toxins in eutrophic water, which
have strong hepatotoxicity. In the past decade, epidemiological and toxicological studies on …

Classical genetic approaches for interpreting variants, such as case-control or co-
segregation studies, require finding many individuals with each variant. Because the …

Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …

Protein-protein interactions govern almost all cellular functions. These complex networks of
stable and transient associations can be mapped by affinity purification mass spectrometry …

Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Proximity labeling proteomics (PLP) strategies are powerful approaches to yield snapshots
of protein neighborhoods. Here, we describe a multiscale PLP method with adjustable …

Metastatic disease represents the major cause of death in oncologic patients worldwide.
Accumulating evidence have highlighted the relevance of a small population of cancer cells …

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …