Malaria causes much physical and economic hardship in tropical regions, particularly in
communities where medical care is rudimentary. Should a vaccine be developed, it is the …

The first scientific attempts to control an infectious disease can be attributed to Edward
Jenner, who, in 1796 inoculated an 8-year-old boy with cowpox (vaccinia), giving the boy …

Publisher Summary This chapter focuses on the basic studies and applications of DNA
vaccines for viral infections. DNA-based vaccines use bacterial plasmids to express protein …

Immunity to Trypanosoma cruzi requires elicitation of humoral and cell-mediated immune
responses to extracellular trypomastigotes and intracellular amastigotes. In this study, the …

The introduction of DNA vaccine technology has facilitated an unprecedented multi-antigen
approach to developing an effective vaccine against complex pathogens such as the …

Non-human primates represent a valuable resource for testing potential vaccines
candidates and drugs for human use. Malaria remains one of the greatest burdens for the …

A DNA vaccine that expresses the premembrane/membrane (prM) and envelope (E) genes
of dengue virus serotype-1 was tested for immunogenicity and protection against dengue-1 …

A candidate DNA vaccine expressing dengue virus type 1 pre-membrane and envelope
proteins was used to immunize rhesus macaques. Monkeys were immunized …

We compared the needle free jet device device Biojector™ with syringe/needle as a method
to administer a DNA vaccine encoding the Plasmodium falciparum circumsporozoite protein …

Background Attempts to optimize DNA vaccines in mice include using different routes of
administration and different formulations. It may be more relevant to human use to carry such …