The development of new CRISPR–Cas genome editing tools continues to drive major
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …

Insertion sequences (ISs), arguably the smallest and most numerous autonomous
transposable elements (TEs), are important players in shaping their host genomes. This …

Integrative and conjugative elements (ICEs) are a diverse group of mobile genetic elements
found in both Gram-positive and Gram-negative bacteria. These elements primarily reside in …

Type IV secretion systems (T4SS) translocate DNA and protein substrates across prokaryotic
cell envelopes generally by a mechanism requiring direct contact with a target cell. Three …

RNase H belongs to a nucleotidyl-transferase superfamily, which includes transposase,
retroviral integrase, Holliday junction resolvase, and RISC nuclease Argonaute. We report …

We have divided this review into two major sections. In one, we have attempted to present
an overview of our current understanding of prokaryotic insertion sequences (IS), their …

Though they started out as somewhat mysterious components of the RNAi effector
complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They …

The HAD (haloacid dehalogenase) superfamily includes phosphoesterases, ATPases,
phosphonatases, dehalogenases, and sugar phosphomutases acting on a remarkably …

Abstract V (D) J recombination is the process by which the variable region exons encoding
the antigen recognition sites of receptors expressed on B and T lymphocytes are generated …

Transposons are ubiquitous in prokaryotic and eukaryotic organisms and are major
determinants of genome structure. Transposition—the movement of discrete segments of …