Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation

AA Gibb, MP Lazaropoulos, JW Elrod - Circulation research, 2020 - Am Heart Assoc
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

The heterocellular heart: identities, interactions, and implications for cardiology

A Lother, P Kohl - Basic Research in Cardiology, 2023 - Springer
The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

QJ Zhang, TAT Tran, M Wang, MJ Ranek… - Nature …, 2018 - nature.com
Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and
mortality. Pathological LVH engages transcriptional programs including reactivation of …

Gene therapy for regenerative medicine

H Hosseinkhani, AJ Domb, G Sharifzadeh, V Nahum - Pharmaceutics, 2023 - mdpi.com
The development of biological methods over the past decade has stimulated great interest in
the possibility to regenerate human tissues. Advances in stem cell research, gene therapy …

Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway

L Lu, H Wang, X Liu, L Tan, X Qiao, J Ni, Y Sun… - Journal of …, 2021 - Springer
Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe
complication, which involves pathological damage to the brain and cognitive function …

Cardiac fibrosis and cardiac fibroblast lineage-tracing: recent advances

X Fu, Q Liu, C Li, Y Li, L Wang - Frontiers in physiology, 2020 - frontiersin.org
Cardiac fibrosis is a common pathological change associated with cardiac injuries and
diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) …

Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis

Q Bao, B Zhang, Y Suo, C Liu, Q Yang, K Zhang… - elife, 2020 - elifesciences.org
Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive
sleep apnea (OSA), known to be independently associated with cardiovascular diseases …

Regulatory role and translational potential of CCL11 in liver fibrosis

M Kong, W Dong, A Kang, Y Kuai, T Xu, Z Fan, L Shi… - Hepatology, 2023 - journals.lww.com
Regulatory role and translational potential of CCL11 in live... : Hepatology Regulatory role and
translational potential of CCL11 in liver fibrosis : Hepatology AASLD Publications Hepatology …

Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage

BY Ding, CN Xie, JY Xie, ZW Gao, XW Fei… - Neural regeneration …, 2023 - journals.lww.com
Intracerebral hemorrhage is often accompanied by oxidative stress induced by reactive
oxygen species, which causes abnormal mitochondrial function and secondary reactive …

The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse …

X Zhang, S Yuan, H Li, J Zhan, F Wang, J Fan… - … and Targeted Therapy, 2021 - nature.com
MicroRNAs (miRNAs) are aberrantly expressed in the pathophysiologic process of heart
failure (HF). However, the functions of a certain miRNA in different cardiac cell types during …