Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
The heterocellular heart: identities, interactions, and implications for cardiology
The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …
Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
QJ Zhang, TAT Tran, M Wang, MJ Ranek… - Nature …, 2018 - nature.com
Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and
mortality. Pathological LVH engages transcriptional programs including reactivation of …
mortality. Pathological LVH engages transcriptional programs including reactivation of …
Gene therapy for regenerative medicine
H Hosseinkhani, AJ Domb, G Sharifzadeh, V Nahum - Pharmaceutics, 2023 - mdpi.com
The development of biological methods over the past decade has stimulated great interest in
the possibility to regenerate human tissues. Advances in stem cell research, gene therapy …
the possibility to regenerate human tissues. Advances in stem cell research, gene therapy …
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway
L Lu, H Wang, X Liu, L Tan, X Qiao, J Ni, Y Sun… - Journal of …, 2021 - Springer
Background Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe
complication, which involves pathological damage to the brain and cognitive function …
complication, which involves pathological damage to the brain and cognitive function …
Cardiac fibrosis and cardiac fibroblast lineage-tracing: recent advances
X Fu, Q Liu, C Li, Y Li, L Wang - Frontiers in physiology, 2020 - frontiersin.org
Cardiac fibrosis is a common pathological change associated with cardiac injuries and
diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) …
diseases. Even though the accumulation of collagens and other extracellular matrix (ECM) …
Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis
Q Bao, B Zhang, Y Suo, C Liu, Q Yang, K Zhang… - elife, 2020 - elifesciences.org
Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive
sleep apnea (OSA), known to be independently associated with cardiovascular diseases …
sleep apnea (OSA), known to be independently associated with cardiovascular diseases …
Regulatory role and translational potential of CCL11 in liver fibrosis
M Kong, W Dong, A Kang, Y Kuai, T Xu, Z Fan, L Shi… - Hepatology, 2023 - journals.lww.com
Regulatory role and translational potential of CCL11 in live... : Hepatology Regulatory role and
translational potential of CCL11 in liver fibrosis : Hepatology AASLD Publications Hepatology …
translational potential of CCL11 in liver fibrosis : Hepatology AASLD Publications Hepatology …
Knockdown of NADPH oxidase 4 reduces mitochondrial oxidative stress and neuronal pyroptosis following intracerebral hemorrhage
BY Ding, CN Xie, JY Xie, ZW Gao, XW Fei… - Neural regeneration …, 2023 - journals.lww.com
Intracerebral hemorrhage is often accompanied by oxidative stress induced by reactive
oxygen species, which causes abnormal mitochondrial function and secondary reactive …
oxygen species, which causes abnormal mitochondrial function and secondary reactive …
The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse …
X Zhang, S Yuan, H Li, J Zhan, F Wang, J Fan… - … and Targeted Therapy, 2021 - nature.com
MicroRNAs (miRNAs) are aberrantly expressed in the pathophysiologic process of heart
failure (HF). However, the functions of a certain miRNA in different cardiac cell types during …
failure (HF). However, the functions of a certain miRNA in different cardiac cell types during …